Key Moments
The Red Devils' poor recent struggles continued at Elland Road, but head coach Ruben Amorim had Matheus Cunha to thank for the team not suffering even more disappointment against their old rivals.
The Everton loanee directed a first-period attempt against the post for the confident hosts before the American midfielder applied a cool finish with a low, 62nd-minute shot.
At that stage, Amorim was in the firing line after his side had been held by struggling Wolves at home earlier in the week.
Nevertheless, against a team who had less time to prepare, the forward restored parity three minutes after the opener when he ran on to a pass from substitute Joshua Zirkzee and slid a shot underneath rushing home goalkeeper Lucas Perri.
It was only the Brazilian's fourth goal since his big-money summer move and came at a time when the manager is without several key attacking players due to a mix of injury and international duty.
Not that Leeds to sympathise with that given their own lack of preparation time.
The Swiss attacker forced a diving save out of Manchester United goalkeeper Senne Lammens with a audacious overhead kick, and visiting heads were in hands when Benjamin Sesko, who is struggling to make an impact, turned Zirkzee's cut-back wide from close range.
The goalscorer, who had a goal ruled out for offside much earlier in the match, also blasted against a post in the dying moments.
The draw prolongs Leeds' unbeaten run to seven games, their longest such streak since over two decades ago, and takes them a significant margin clear of the relegation zone.
For the visitors though, it was yet another chance to move into fourth spot, albeit only for a short time, wasted.
With the AFCON reaching its knockout phase, Amorim could be forgiven for hoping the involved countries make a pretty quick exit.
Current injuries to skipper Bruno Fernandes and Three Lions star Mason Mount only heightened the impact the unavailability of other forwards is having on Amorim's options.
It's not that the missing pair are the answer to all of the club's problems. After all, they were part of the side that experienced disappointing results earlier in the campaign.
But without them, Amorim has few attacking options.
He evidently does not trust youngster Shea Lacey or the much more experienced Joshua Zirkzee, even though the Netherlands forward provided the through ball for Cunha's equaliser almost immediately after his arrival as a replacement.
That leaves the Brazilian, who has now scored three goals in five games, and others playing out of their natural positions, alongside Sesko.
On this showing, the expensive frontman looks similar to previous struggling signings, lacking in confidence and conviction in front of goal.
His failure to turn home the cross means it is now nine games without a goal for the new signing.
After memorable victories in their last few home games, the arrival of their fiercest rivals to home was a comparatively subdued affair.
True, there were moments of expected fervor, but the hostile edge was not as pronounced as in other encounters.
The home fans were more concerned about their side's inability to get sustained possession in dangerous areas for any length of time.
The Calvert-Lewin header that struck the post was an rare moment of threat in a tight first half.
It still felt as though Leeds were finding it tough when a mistake opened the door for the opener.
Ever so briefly, The home delirious fans thought they were about to secure a rare win against Manchester United.
However, there is a much bigger picture for Daniel Farke and the club to deal with.
When they endured a poor run of form earlier in the campaign, many speculated about the manager's future.
In contrast, he is now overseeing clear progress.
The task is not completed yet but gradually, Leeds are getting closer to securing their top-flight status.
Leeds have a top-flight trip to St James' Park in midweek, followed by the start of their FA Cup campaign next weekend. Manchester United face a Premier League trip to Turf Moor before also beginning their FA Cup journey with a home tie.
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